Preheat your oven to 350°F (175°C).
In a large bowl, combine ground turkey, breadcrumbs, and Parmesan cheese.
Add the chopped onion, egg, milk, garlic powder, oregano, salt, and pepper.
Mix all ingredients until just combined.
Transfer the mixture into a loaf pan and shape it into a loaf.
Spread ketchup evenly over the top of the meatloaf.
Bake in the preheated oven for 60 minutes.
Check for doneness by ensuring it reaches an internal temperature of 165°F (74°C).
Remove from oven and let it rest for 10 minutes before slicing.
Serve with your favorite sides.