Preheat the oven to 375°F (190°C).
In a large bowl, combine ground meat, breadcrumbs, egg, garlic powder, onion powder, salt, and pepper.
Mix well until all ingredients are thoroughly incorporated.
Shape the mixture into small meatballs, about 1 inch in diameter.
Place the meatballs on a baking sheet lined with parchment paper.
Bake the meatballs for 20 minutes or until cooked through.
While meatballs are baking, prepare the sweet and sour sauce.
In a saucepan, combine ketchup, vinegar, sugar, and soy sauce.
Heat the sauce over medium heat until it thickens slightly.
Once meatballs are done, toss them in the sweet and sour sauce before serving.