Preheat your grill or skillet over medium-high heat.
In a large bowl, combine ground beef, salt, pepper, garlic powder, and onion powder.
Gently mix until just combined; avoid overworking the meat.
Divide the mixture into four equal portions and shape them into patties.
Make a small indentation in the center of each patty to prevent puffing during cooking.
Place the patties on the grill or skillet.
Cook for about 4-5 minutes on one side, then flip.
Add cheese slices on top, if desired, and cook for another 3-4 minutes.
Toast hamburger buns on the grill for 1-2 minutes.
Assemble your burgers with lettuce, tomato, onion, and pickles.