Rinse the chicken wings under cold water and pat dry with paper towels.
In a bowl, mix flour, paprika, garlic powder, onion powder, salt, and black pepper.
Pour the buttermilk into another bowl.
Dip each wing into the buttermilk, letting excess drip off.
Coat each wing in the flour mixture.
Place the coated wings on a baking sheet and let rest for 10 minutes.
Heat oil in a deep fryer or heavy pot to 350°F (175°C).
Carefully add wings to the hot oil, ensuring not to overcrowd.
Fry wings for 10-12 minutes until golden brown.
Remove wings and place on a paper towel-lined plate to drain.